A framework to evaluate the impact of uncertainty on design and operation of reactive distillation systems

This work is motivated by the current obstacles hindering implementation of reactive distillation in industry, mainly related to complexities its design and control, as well impact uncertainties thereupon. A framework systematically investigate uncertainty on processes presented, considering relevant control system potential redesign column, possibly including additional ancillary equipment, with aim make process more robust mitigate risk. The also considers operational uncertainties, showing that a which can tolerate may nevertheless still be sensitive case mitigation strategies presented this should applied enhance robustness. used an early stage quantify specific input parameters performance costs, it therefore steer experimental focus determining most critical for process. Three studies are considered that, distillation, rate constant has significant than similar chemical equilibrium.